BRIEF OBSERVATION Baclofen in the Treatment of Alcohol Withdrawal Syndrome: A Comparative Study vs Diazepam Giovanni Addolorato, MD, aLorenzo Leggio, MD, Ludovico Abenavoli, MD,a Roberta Agabio, MD,b Fabio Caputo, MD,c A short course of baclofen can quickly neutralize alcohol withdrawal symptoms, with fewer risks than standard-of-care treatment. User Reviews for Baclofen to treat Alcohol Withdrawal (Page 2) Also known as: FIRST Baclofen, Lioresal, Lioresal Intrathecal, Gablofen. The following information is NOT intended to endorse drugs or recommend therapy. Thus to minimise withdrawal symptoms, the dose should be tapered down slowly when discontinuing baclofen therapy. Abrupt withdrawal is more likely to result in severe withdrawal symptoms. Acute withdrawal symptoms can be stopped by recommencing baclofen. The patient will finish the withdrawal period at a dose of 10mg three times a day and can then start the Ameisen regime second part, the more rapid titration of the baclofen dose up until alcohol cravings are suppressed. Baclofen shows potential for rapidly reducing symptoms of severe alcohol withdrawal syndrome (AWS) in people with alcoholism. Treatment with baclofen is easy to manage and rarely produces euphoria or other pleasant effects, or craving for the drug. The simplest way to use baclofen is to keep the alcohol intake stable to start with and watch the effect on alcohol cravings and alcohol intake as the baclofen dose rises. The alcohol intake generally drops steadily and any withdrawal is avoided. Baclofen, particularly high-dose baclofen, has recently emerged as a treatment of major interest for alcohol-dependence. However, baclofen has many potentially dangerous side effects, and the maximal dose of baclofen that may be used is a matter of discussion. After several trips to rehab and AA over 18 years, I discovered Baclofen for alcohol withdrawal and it works - it's changed my life. I had some success through traditional means but I always fell back because I never stopped craving alcohol. Baclofen (30 mg/day for 10 consecutive days) was orally administered to 18 patients (15 males, 3 females; median age: 46.5 years). Diazepam (0.5-0.75 mg/kg/day for 6 consecutive days, tapering the dose by 25% daily from day 7 to day 10) was orally administered to 19 patients (17 men, 2 women; median age: 42.0 years). The Clinical Institute Withdrawal Assessment (CIWA-Ar) was used to evaluate.